Abramson Family Cancer Research Institute at the University of Pennsylvania Cancer Center


administrative contact

Name: Erin Quinn
Phone: 215-573-2281
Fax: (215) 746-5525
Email: erinq@mail.med.upenn.edu

diehl lab contact

Name: Diehl Lab
Phone: (215) 746-6393
Fax: (215) 746-5525
Email: adiehl@mail.med.upenn.edu
Address: Abramson Family Cancer Research Institute 421 Curie Boulevard
Philadelphia, PA 19104-6160
Lab Manager: Margarita Romero

diehl lab staff page

news and publications

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Name: J. Alan Diehl, Ph.D.
Title/Titles: Professor, Department of Cancer Biology
Director and Investigator, Cancer Cell Biology Program, Abramson Family Cancer Research Institute
Phone: (215) 746-6389
Fax: (215) 746-5525
Email: adiehl@mail.med.upenn.edu

lab overview

The laboratory of J. Alan Diehl, Ph.D. focuses on the mechanisms whereby extra-cellular signals are sensed by the cell cycle machine and are then transmitted into regulated cell cycle progression. This information will provide the framework necessary to elucidate how growth regulatory pathways are subverted in neoplasia. more

View Diehl biographical sketch

Selected Publications

Hamanaka RB, Bobrovnikova-Marjon E, Ji X, Liebhaber SA, Diehl JA: PERK-dependent regulation of IAP translation during ER stress. Oncogene 28(6): 910-20, February 2009 Notes: Epub 2008 Nov 24.

Pontano LL, Aggarwal P, Barbash O, Brown EJ, Bassing CH, Diehl JA: Genotoxic stress-induced cyclin D1 phosphorylation and proteolysis are required for genomic stability. Molecular and Cellular Biology 28(23): 7245-58, December 2008 Notes: Epub 2008 Sep 22.

Barbash O, Zamfirova P, Lin DI, Chen X, Yang K, Nakagawa H, Lu F, Rustgi AK, Diehl JA: Mutations in Fbx4 inhibit dimerization of the SCF(Fbx4) ligase and contribute to cyclin D1 overexpression in human cancer. Cancer Cell 14(1): 68-78, July 2008.

Bobrovnikova-Marjon E, Hatzivassiliou G, Grigoriadou C, Romero M, Cavener DR, Thompson CB, Diehl JA: PERK-dependent regulationof lipogenesis during mouse mammary gland development and adipocyte differentiation. Proceedings of the National Academy of Sciences of the United States of America 105(42): 16314-9, October 2008 Notes: Epub 2008 Oct 13.

Lin DI, Aggarwal P, Diehl JA : Phosphorylation of MCM3 on Ser-112 regulates its incorporation into the MCM2-7 complex. Proceedings of the National Academy of Sciences of the United States of America 105(23): 8079 - 8084, June 2008.

Aggarwal P, Lessie M, Lin DI, Pontano L, Gladden AB, Nuskey B, Goradia A, Wasik MA, Klein-Szanto AJP, Rustgi AK, Bassing CH, Diehl JA: Nuclear accumulation of cyclin D1 during S-phase inhibits Cdt1 proteolysis and triggers p53-dependent DNA re-replication. Genes & Development 21: 2908-2922 November 2007.

Lin DI, Barbash O, Kumar KG, Weber JD, Harper JW, Klein-Szanto AJP, Rustgi A, Fuchs SY, Diehl JA: Phosphorylation-dependent ubiquitination of cyclin D1 by the SCF (FBX4-alphaB crystallin) complex. Molecular Cell 24(3): 355-366 November 2006.

Bobrovnikova-Marjon E, Diehl JA: Coping with stress: ATF6 takes the stage. Developmental Cell 13: 322-324, September 2007.

Gladden AB, Woolery R, Aggarwal P, Wasik MA, Diehl JA: Expression of constitutively nuclear cyclin D1 in murine lymphocytes induces B-cell lymphoma. Oncogene 25: 998-1007 February 2006.

Zhang F, Hamanaka RB, Bobrovnikova-Marjon E, Gordan J, Dai MS, Lu H, Simon MC, Diehl JA: Ribosomal stress couples the unfolded protein response to p53-dependent cell cycle arrest. Journal of Biological Chemistry 281: 30036-30045, October 2006.