|Name:||Carl H. June, M.D.|
|Title/Titles:||Program Director of Translational Research
Abramson Family Cancer Research Institute,
Professor, Department of Pathology and Laboratory Medicine
June lab overview
The June Laboratory provides researchers with the tools they need to translate laboratory insights into safe and effective cancer therapies. The June Laboratory works with University of Pennsylvania faculty members interested in moving biologically-focused research ideas into clinical trials. In addition, the June Laboratory has a cadre of faculty researchers focused on developing ways to enhance the ability of the natural immune system to recognize and eliminate tumor cells. more
Carl June is currently Director of Translational Research at the Abramson Cancer Center at the University of Pennsylvania, and is an Investigator of the Abramson Family Cancer Research Institute. He is a graduate of the Naval Academy in Annapolis, and Baylor College of Medicine in Houston, 1979. He had graduate training in Immunology and malaria with Dr. Paul-Henri Lambert at the World Health Organization, Geneva, Switzerland from 1978-79, and post-doctoral training in transplantation biology with Dr. E. Donnell Thomas at the Fred Hutchinson Cancer Research Center in Seattle from 1983 - 1986. He is board certified in Internal Medicine and Medical Oncology. He founded the Immune Cell Biology Program and was head of the Department of Immunology at the Naval Medical Research Institute from 1990 to 1995. He rose to Professor in the Departments of Medicine and Cell and Molecular Biology at the Uniformed Services University for the Health Sciences in Bethesda, Maryland before assuming his current position as of February 1, 1999. He maintains a research laboratory that studies various mechanisms of lymphocyte activation that relate to immune tolerance and adoptive immunotherapy.
Kalos M, Levine BL, Porter DL, Katz S, Grupp SA, Bagg A, June CH: T cells with chimeric antigen receptors have potent antitumor effects and can establish memory in patients with advanced leukemia. Sci Transl Med. 2011 Aug 10;3(95):95ra73. PubMed PMID: 21832238.
Porter DL, Levine BL, Kalos M, Bagg A, June CH: Chimeric Antigen Receptor-Modified T Cells in Chronic Lymphoid Leukemia. N Engl J Med. 2011 Aug 10. [Epub ahead of print] PubMed PMID: 21830940.
Milone MC, Fish JD, Carpenito C, Carroll RG, Binder GK, Teachey D, Samanta M, Lakhal M, Gloss B, Danet-Desnoyers G, Campana D, Riley JL, Grupp SA, June CH: Chimeric Receptors Containing CD137 Signal Transduction Domains Mediate Enhanced Survival of T Cells and Increased Antileukemic Efficacy In Vivo. Molecular Therapy 17(8): 1453-64, May 2009 Notes: PMID: 1938429.
June CH, Blazar BR, Riley JL: Engineering lymphocyte subsets: tools, trials and tribulations. Nature Reviews Immunology 9(10): 704-16, Oct 2009.
Carpenito Carmine, Milone Michael C, Hassan Raffit, Simonet Jacqueline C, Lakhal Mehdi, Suhoski Megan M, Varela-Rohena Angel, Haines Kathleen M, Heitjan Daniel F, Albelda Steven M, Carroll Richard G, Riley James L, Pastan Ira, June Carl H: Control of large, established tumor xenografts with genetically retargeted human T cells containing CD28 and CD137 domains. Proceedings of the National Academy of Sciences of the United States of America 106(9): 3360-5, Mar 2009.
Varela-Rohena, A, Molloy, PE, Dunn, SM, Li, Y, Suhoski, MM, Carroll, RG, Milicic, A, Mahon, T, Sutton, DH, Laugel, B, Moysey, R, Cameron, BJ, Vuidepot, A, Purbhoo, MA, Cole, DK, Phillips, RE, June, CH, Jakobsen, BK, Sewell, AK, Riley, JL: Control of HIV-1 immune escape by CD8 T cells expressing enhanced T-cell receptor. Nature Medicine 14(12): 1390-1395, Dec 2008.
Perez EE, Wang J, Miller JC, Jouvenot Y, Kim KA, Liu O, Wang N, Lee G, Bartsevich VV, Lee YL, Guschin DY, Rupniewski I, Waite AJ, Carpenito C, Carroll RG, Orange JS, Urnov FD, Rebar EJ, Ando D, Gregory PD, Riley JL, Holmes MC, June CH.: Establishment of HIV-1 resistance in CD4+ T cells by genome editing using zinc-finger nucleases. Nat Biotechnol. 7: 808-16, Jul. 26 2008.
Carroll,R.G., Carpenito,C., Shan,X., net-Desnoyers,G., Liu,R., Jiang,S., Albelda,S.M., Golovina,T., Coukos,G., Riley,J.L., Jonak, Z.L., June, C.H.: Distinct effects of IL-18 on the engraftment and function of human effector CD8 T cells and regulatory T cells PLoS ONE 3(9): e3289-98, Oct 2008.
Suhoski, Megan M. Golovina, Tatiana N. Aqui, Nicole A. Tai, Victoria C. Varela-Rohena, Angel. Milone, Michael C. Carroll, Richard G. Riley, James L. June, Carl H.: Engineering artificial antigen-presenting cells to express a diverse array of co-stimulatory molecules. Molecular Therapy: the Journal of the American Society of Gene Therapy 15(5): 981-8, May 2007.
Levine, Bruce L. Humeau, Laurent M. Boyer, Jean. MacGregor, Rob-Roy. Rebello, Tessio. Lu, Xiaobin. Binder, Gwendolyn K. Slepushkin, Vladimir. Lemiale, Franck. Mascola, John R. Bushman, Frederic D. Dropulic, Boro. June, Carl H.: Gene transfer in humans using a conditionally replicating lentiviral vector. Proceedings of the National Academy of Sciences of the United States of America 103(46): 17372-7, Nov 14 2006.
Rapoport, Aaron P. Stadtmauer, Edward A. Aqui, Nicole. Badros, Ashraf. Cotte, Julio. Chrisley, Lisa. Veloso, Elizabeth. Zheng, Zhaohui. Westphal, Sandra. Mair, Rebecca. Chi, Nina. Ratterree, Bashi. Pochran, Mary Francis. Natt, Sabrina. Hinkle, Joanne. Sickles, Cheryl. Sohal, Ambika. Ruehle, Kathleen. Lynch, Christian. Zhang, Lei. Porter, David L. Luger, Selina. Guo, Chuanfa. Fang, Hong-Bin. Blackwelder, William. Hankey, Kim. Mann, Dean. Edelman, Robert. Frasch, Carl. Levine, Bruce L. Cross, Alan. June, Carl H.: Restoration of immunity in lymphopenic individuals with cancer by vaccination and adoptive T-cell transfer.[see comment]. Nature Medicine 11(11): 1230-7, Nov 2005.
Levine BL., Bernstein WB., Aronson NE., Schlienger K., Cotte J., Perfetto S., Humphries MJ., Ratto-Kim S., Birx DL., Steffens C., Landay A., Carroll RG., June CH.: Adoptive transfer of costimulated CD4+ T cells induces expansion of peripheral T cells and decreased CCR5 expression in HIV infection. Nature Medicine 8(1): 47-53, Jan 2002.