THE JUNE LABORATORY
Under Carl H. June, M.D., the translational research team has accelerated the pace in bringing research advances to the clinical setting. The group focuses on developing cancer vaccines. Supporting this effort is the vaccine production facility, led by Bruce Levine, Ph.D., which manufactures vaccines for individual patients.
Through innovative clinical trials, the team is assessing the effectiveness of strategies for enhancing the immune system's ability to recognize and eliminate tumor cells. One new therapy under evaluation, called adoptive immunotherapy, uses a patient's own white blood cells to attack cancer cells. The patient's white blood cells are stimulated in the laboratory and then given back to the patient via transfusion. Another approach being tested is customized vaccination. Abramson immunologists are working with Penn thoracic surgeons and medical oncologists to develop treatment vaccines for patients with non-small cell lung cancer whose tumors cannot be removed surgically or whose cancer has spread. The team is using the patient's own tumor tissue to create a vaccine customized for that individual. This approach is having promising clinical and scientific results.
Most ovarian tumors are responsive to chemotherapy, giving patients long remissions. For those whose cancer recurs, Abramson immunologists are working with Penn gynecologic surgeons and oncologists to develop immune-based therapies. These include the development of a vaccine using donor T cells, injection of the chemotherapy agent interleukin 12 directly into the abdominal cavity rather than through the vein, and the use of white blood cells called dendritic cells to increase the effectiveness of vaccines.
Clinical Trials at the Abramson Institute
Oncolink - Clinical Trials Information Information about participating in a trial at the University of Pennsylvania
Cancer Trial: A Service of the National Cancer Institute nformation about cancer clinical trials
OncoLink - Lung Cancer
CancerNet - Lung Cancer
OncoLink - Ovarian Cancer
CancerNet - Ovarian Cancer