Abramson Family Cancer Research Institute at the University of Pennsylvania Cancer Center

administrative contact

Name: Caitlin O'Neill
Phone: (215) 746-8675

pear lab contact

Name: Pear Lab
Phone: (215) 746-6578
Fax: (215) 573-6725
Address: Abramson Family Cancer Research Institute
421 Curie Boulevard
Philadelphia, PA 19104-6160
Lab Manager: Lanwei Xu

pear lab staff page

news and publications

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Warren S. Pear of the Abramson Family Cancer Research Institute Name: Warren S. Pear, M.D., Ph.D.
Title/Titles: Professor of Pathology and Laboratory Medicine
Phone: (215) 573-7764
Fax: (215) 573-6725

lab overview

The multiple types of cells in the blood (lymphocytes, neutrophils, red blood cells) derive from a single hematopoietic stem cell. The process by which the hematopoietic stem cell differentiates into these multiple lineages is orchestrated by transcription factors, cytokines, growth factors, and other extracellular cues. Because the hematopoietic system must rapidly respond to insults, such as infections and trauma, this system is regulated at multiple levels. More

View pear biographical sketch

Selected Publications

Liu H., Chi W.S., Chiang M.Y., Arnett K.L., Xu L., Shestova O., Wang H., Li Y.M., Bhandoola A., Aster J.C., Blacklow S.C., Pear W.S.: Notch dimerization is required for leukemogenesis and T cell development. Genes Dev. in press.

Dedhia P.H., Keeshan K., Uljon S., Xu L., Vega M.E., Shestova O., Zaks-Zilberman M., Romany C., Blacklow S.C., Pear W.S.: Differential ability of Tribbles family members to promote degradation of C/EBP{alpha} and induce acute myelogenous leukemia. Blood 116: 1321-8, 2010.

Yashiro-Ohtani Y., He Y., Ohtani T., Jones M.E., Shestova O., Xu L., Fang T.C., Chiang M.Y., Intlekofer A.M., Blacklow S.C., Zhuang Y., Pear W.S.: Pre-TCR signaling inactivates Notch1transcription by antagonizing E2A. Genes Dev. 23: 1665-76, 2009.

Chiang M.Y., Xu L., Shestova O., Histen G., L’Heureux S., Romany C., Childs M.E., Gimotty P.A., Aster J.C., Pear W.S.: Leukemia-associated Notch1 alleles are weak tumor initiators but accelerate K-ras-initiated leukemia. J Clin Invest. 118: 3181-94, 2008.

Maillard I., Koch U., Dumortier A., Shestova O., Xu L., Sai H., Pross S.E., Aster J.C., Bhandoola A., Radtke F., Pear W.S.: Canonical Notch signaling is dispensable for the maintenance of adult hematopoietic stem cells. Cell Stem Cell 2: 356-66, 2008.

Aster J.C., Pear W.S., Blacklow S.C.: Notch signaling in leukemia. Annu Rev Pathol. 3: 587-613, 2008.

Fang T.C., Ohtani Y., Del Bianco C., Knoblock D., Blacklow S.C., Pear W.S.: Notch directly regulates Gata3 expression during T helper 2 cell differentiation. Immunity 27: 100-10, 2007.

Keeshan K., He Y., Wouters B.J., Shestova O., Xu L., Sai H., Rodriguez C., Maillard I., Tobias J.W., Valk P., Carroll M., Aster J.C., Delwel R., Pear W.S.: Tribbles homologue 2 (Trib2) inactivates C/EBPalpha and causes acute myelogenous leukemia. Cancer Cell 10: 401-11, 2006.

Weng A.P., Millholland J.M., Yashiro-Ohtani Y., Arcangeli M.L., Lau A., Wai C., del Bianco C., Rodriguez C.G., Sai H., Tobias J., Li Y., Wolfe M.S., Shachaf C., Felsher D., Blacklow S.C., Pear W.S.*, Aster J.C.*: c-Myc is an important direct target of Notch1 in T cell acute lymphoblastic leukemia/lymphoma. Genes Dev. 20: 2096-109, 2006 Notes: *corresponding authors.