|Name:||Ben Z. Stanger, M.D., Ph.D.|
|Title/Titles:||Assistant Professor of Medicine,
DM-Gastroenterology The Hospital of the University of Pennsylvania
Assistant Investigator, Abramson Family Cancer Research Institute
Stem/Progenitor Cells in Development and Disease As the tissue responsible for two common diseases – type I diabetes and pancreatic adenocarcinoma – the pancreas has been the focus of intense study to understand cell lineage relationships. We have previously shown that Notch signaling is a key embryonic regulator of pancreatic progenitor cells, the cells that give rise to all of the mature cell types of the pancreas (exocrine, endocrine, and duct cells). Furthermore, our studies in a mouse model of pancreatic cancer have pointed to the potential importance of pancreatic centroacinar cells in the pathogenesis of pancreatic cancer. Current studies are aimed at further understanding cellular lineage relationships in pancreatic cancer and pancreatic regeneration and exploring the biology of pancreatic centroacinar cells. more
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Selected PublicationsZong Y, Panikkar A, Xu J, Antoniou A, Raynaud P, Lemaigre F, and Stanger BZ.: Notch signaling controls liver development by regulating biliary differentiation. Development 136(10): 1727-39, 2009.
Antoniou A, Raynaud P, Cordi S, Zong Y, Tronche F, Stanger B, Jacquemin P, Pierreux CE, Clotman F, and Lemaigre FP.: Intrahepatic bile ducts develop according to a new mode of tubulogenesis regulated by the transcription factor SOX9. Gastroenterology 136(7): 2325-33, 2009.
Guseh JS, Bores SA, Stanger BZ, Zhou Q, Anderson WJ, Melton DA, and Rajagopal J.: Notch signaling promotes airway mucous metaplasia and inhibits alveolar development. Development 136(10): 1751-9, 2009.
Plentz R, Park JS, Rhim AD, Abravanel D, Hezel AF, Sharma SV, Gurumurthy S, Deshpande V, Kenific C, Settleman J, Majumder PK, Stanger BZ*, and Bardeesy N: Inhibition of g-secretase activity inhibits tumor progression in a mouse model of pancreatic ductal adenocarcinoma. Gastroenterology 136(5): 1741-9, 2009 Notes: *co-corresponding author.
Stanger BZ: Organ size determination and the limits of regulation. Cell Cycle 7: 543-46, 2008.
Stanger, BZ, Tanaka, AJ, and Melton, DA: Organ size is limited by the number of embryonic progenitor cells in the pancreas but not the liver. Nature 445(7130): 886-91, 2007.
Dor Y, and Stanger BZ: Regeneration in liver and pancreas: Time to cut the umbilical cord? Science STKE Page: pe66, 2007.
Stanger BZ, and Podolsky DK: Development of the gastrointestinal system. Yamada T, Alpers DH, Kalloo AN, Kaplowitz N, Owyang C, Powell DW eds. Textbook of Gastroenterology, Wiley-Blackwell Publishing 2009.