 |
Name: | Xiaolu Yang, Ph.D. |
|---|---|---|
| Title/Titles: | Professor, Cancer Biology | |
| Phone: | 215-573-6739 | |
| Fax: | (215) 573-6725 | |
| Email: | xyang@mail.med.upenn.edu |
lab overview
Dr. Yang's laboratory seeks to understand molecular mechanisms of apoptosis. Research Current research projects focus on:
•The enzymes that catalyze the breakdown of the chemical bonds that hold together the cell's protein structure.
•The mechanisms by which the instruction to commit suicide is transmitted from the surface of the cell and translated into action. Death receptors such as Fas and TNFRs (Tumor necrosis factor receptors) play important roles in the regulation of immune responses. more
Selected Publications
Jiang P., Du W., Mancuso A., Wellen K. and Yang X.: Reciprocal regulation of p53 and malic enzymes modulates metabolism and senescence. Nature doi:10.1038/nature11776, 2013.
Jiang P., Du W., Wang X., Mancuso A., Gao X., Wu M., and Yang X.: p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase. Nat Cell Biol. 13: 310-18, 2011 Notes: cover story and featured in News & Views in this issue.
Chu Y. and Yang X.: SUMO E3 activity of TRIM proteins. Oncogene 30: 1108-16, 2011.
Mei Y., Yong J., Liu H., Shi Y., Meinkoth J., Dreyfuss G., and Yang X.: tRNA binds to cytochrome c and inhibits caspase activation. Mol Cell 37: 668-78, 2010 Notes: Cover story and previewed in this issue. Highlighted in Science Signaling and Chemical & Engineering News.
Kawadler H., Riley J. L., and Yang X.: The paracaspase MALT1 control caspase-8 activation during lymphocyte proliferation. Mol Cell 31: 415-21, 2008 Notes: Highlighted in Science Signaling.
Tang J., Qu L., Zhang J., Wang W., Michaelson J. S., Degenhardt Y., El-Deiry W.S., and Yang X.: Critical role for Daxx in regulating Mdm2. Nat Cell Biol. 8: 855-62, 2006 Notes: Featured in News & Views in this issue.
Hu S., Du M.-Q., Park S.-M., Alcivar A., Qu L., Gupta S., Tang J., Baens M., Ye H., Lee T., Marynen P., Riley J.L., and Yang X.: cIAP2 is a ubiquitin protein ligase for BCL10 and is dysregulated in mucosa-associated lymphoid tissue lymphomas. J Clin Invest. 116: 174-81, 2006 Notes: Commented in this issue.
Chang D.W., Xing Z., Capacio V.L., Peter M.E., and Yang X.: Interdimer processing mechanism of procaspase-8 activation. EMBO J. 22: 4132-42, 2003.
Yang X., Chang H.Y., and Baltimore D.: Essential role of CED-4 oligomerization in CED-3 activation and apoptosis. Science 281: 1355-7, 1998.
Yang X., Chang H.Y., and Baltimore D.: Autoproteolytic activation of pro-caspases by oligomerization. Mol Cell 1: 319-25, 1998.