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The Abramson Family Cancer Research Institute at the University of Pennsylvania Cancer Center

Cells of Aggressive Leukemia Hijack Normal Protein to Grow, According to Penn Study


PHILADELPHIA - Researchers have found that one particularly aggressive type of blood cancer, mixed lineage leukemia (MLL), has an unusual way to keep the molecular motors running. The cancer cells rely on the normal version of an associated protein to stay alive. (more)

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Translational Research Divisions:

Carl June, Director


Translational Research:

  • provides researchers with the tools they need to translate laboratory insights into safe and effective cancer therapies;
  • has a cadre of faculty researchers focused on developing ways to enhance the ability of the natural immune system to recognize and eliminate tumor cells;
  • studies the origin of breast cancer and endeavors to use this insight to improve detection and treatment; and
  • identifies and tests the effectiveness of new drugs in preventing or treating cancer.

Translational Research Mission

of Translational Research at the Leonard and Madlyn Abramson Family Cancer Research Institute is to promote patient-based testing of novel molecular and cellular therapies developed at the University of Pennsylvania. The overall goal of Translational Research is to accelerate the pace of advances in cancer therapy by enhancing research in the early stages of translation to the clinical setting. Furthermore, Translational Research will strive to strengthen the links between the strong University-wide foundation in basic research with clinicians and patients. To accomplish this mission, Translational Research will:

  • Serve as a central resource of pertinent information and expertise in cellular therapies for researchers at the University.
  • Assist University faculty with the application of pertinent regulatory requirements for cell based therapies.
  • Provide resources and expertise to University researchers to assist in the translation of their work to the clinical setting in the Cancer Center.

The June Laboratory

The Greene Laboratory

The Coukos Laboratory

The Vonderheide Laboratory

The Riley Laboratory

Bruce L. Levine, Ph.D.

Translational research is a core unit of the The Leonard and Madlyn Abramson Family Cancer Research Institute at the Abramson Cancer Center at the University of Pennsylvania. Created in December 1997 with a $100 million pledge from the Abramson Family Foundation, the Cancer Research Institute integrates research, education, and comprehensive patient care at the Abramson Cancer Center at the University of Pennsylvania. For more information, see the Translational Research Mission Statement.